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This Concept Map, created with IHMC CmapTools, has information related to: Gut Pharm LO Map, Bulk Forming (Cellulose) Mechanism As it gets hydrated, compounds expand and activate stretch receptors and initiate peristalsis, Loperamide (Imodium) TI ~550, Therapeutic Index 2nd Component is ED50=Dose at which 50% of test population would experience desired effect, Laxatives 2 Fecal Softener (Docusate (Correctol)), Gut Pharmacology Loperamide (Imodium), Dicyclomine (Bentyl) Metabolism Glucoronidation, CYP2D6 and CYP3A4, Dicyclomine (Bentyl) Bioavailability 67% By Oral Admin, Therapeutic Index Calculated By LD50/ED50, Dicyclomine (Bentyl) TI ~200, Therapeutic Index 1 Component Is LD50=Dose at which 50% of test population would experience lethal complications, Laxatives 3 Bulk Forming (Cellulose), Loperamide (Imodium) Family Opioid Agonist, Dicyclomine (Bentyl) Family Antimuscarinic Agents, NSAID Mechanism Acetylates COX1 and COX2 inhibiting their action in synthesizing prostaglandins (esp PGE2, Osmotic (Milk of Magnesia (Mg(OH)2) Mechanism Non-absorbable Salts that saty in the lumen and recruit H20 via osmotic pressure, Loperamide (Imodium) Metabolism CYP3A4 and CYP2B6, Opioid Agonist Mechanism Binds mu opioid receptor, prevents presynaptic neurotransimitter exocytosis and hyperpolarizes neurons inhibiting action potential transmission, Antimuscarinic Agents Mechanism Blocks Cholinergic Receptor, inhibits peristalsis, Laxatives 1 Osmotic (Milk of Magnesia (Mg(OH)2), Acetylsalicylic Acid (Aspirin) Bioavailability 68% by Oral Admin